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Crossing chronic total occlusions with a new 0.014″ CiTop guidewire: Proof of concept
Author(s) -
Scheinowitz Mickey,
Amrami Irit,
Oppenhaim Uri,
Engelberg Santiago,
Schwartz Oren,
Belenky Alexander,
SievNer Itzhak
Publication year - 2009
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.21978
Subject(s) - medicine , peripheral , artery , occlusion , amputation , perforation , catheter , coronary arteries , radiology , arterial disease , cardiology , surgery , vascular disease , punching , materials science , metallurgy
Objective: To evaluate the feasibility of a new 0.014″ CiTop™ guidewire to cross total occlusions within normal and diseased blood vessels; proof of concept. Background: Despite recent advances, chronic arterial occlusions remain the main obstacle of coronary and peripheral interventions. Methods: The OVALUM CiTop™ 0.014″ guidewire is an over‐the‐wire catheter designed to penetrate through chronic total occlusions (CTO) and allow for further PCI interventions. The CiTop™ guidewire was tested in normal peripheral and coronary arteries of swine ( n = 7) and in totally occluded arterial lesions within human amputations ( n = 10). Results: The CiTop™ 0.014″ guidewire was operated successfully in seven peripheral blood vessels and 12 coronary arteries without angiographic or histological evidence of damage to the arterial wall. The CiTop™ crossed 9 of the 10 occluded segments within the human amputation with no angiographic or histological evidence of arterial damage (90% success rate). Average time to cross the occlusion was 4.6 ± 5.6 min. In one artery (10%), angiographic evidence of perforation was noted and there was histological evidence for arterial wall damage. Conclusion: Our data show that the new 0.014″ CiTop™ guidewire can be well operated within normal peripheral and coronary arteries of swine, and with minimal complications within totally occluded blood vessels from human amputations while effectively penetrating and crossing total arterial occlusions. © 2009 Wiley‐Liss, Inc.