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Thoracic radiotherapy in patients with lymphoma and restenosis after coronary stent placement
Author(s) -
Schömig Kathrin,
Ndrepepa Gjin,
Mehilli Julinda,
Pache Jürgen,
Kastrati Adnan,
Schömig Albert
Publication year - 2007
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.21109
Subject(s) - medicine , restenosis , coronary artery disease , radiology , cardiology , incidence (geometry) , odds ratio , radiation therapy , stent , surgery , physics , optics
Objectives : The aim of this study was to assess the incidence of restenosis after coronary stenting in patients with lymphoma treated with thoracic radiation. Background : Patients with Hodgkin lymphoma treated with thoracic radiation have an increased incidence of coronary artery disease (CAD). The incidence of restenosis after percutaneous coronary interventions is completely unknown. Methods : This study included 12,626 consecutive patients with CAD treated with coronary stenting during a 10‐year period. Within this cohort, three subgroups of patients were assessed: patients with lymphoma and previous thoracic radiation (15 patients), patients with lymphoma without thoracic radiation (7 patients) and patients without lymphoma or previous thoracic radiation (control group; 12,604 patients). Coronary stenting was performed after a median [25th; 75th percentiles] of 8 years [4; 17] after thoracic radiation. The primary end point of the study was restenosis at 6‐month coronary angiography. Results : Six‐month coronary angiography was performed in 14 patients (93%) in the group with lymphoma and radiation, 6 patients (86%) in the group with lymphoma without radiation and 10,032 patients (80%) in the control group ( P = 0.38). Angiographic restenosis was found in 12 patients (85.7%) in the group with lymphoma and radiation, 1 patient (16.7%) in the group with lymphoma without radiation and 2,555 patients (25.5%) in the control group ( P < 0.001). Multiple logistic regression identified thoracic radiation as an independent predictor of coronary restenosis (odds ratio 21.7, 95% confidence interval, 4.7–100.9, P < 0.001). Conclusions : Patients with lymphoma treated with thoracic radiation have an increased risk of restenosis after coronary artery stenting. © 2007 Wiley‐Liss, Inc.