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Quantitative assessment of regional left ventricular function with cardiac MRI: Three‐dimensional centersurface method
Author(s) -
Beohar Nirat,
Flaherty James D.,
Davidson Charles J.,
Vidovich Mladen I.,
Brodsky Adam,
Lee Daniel C.,
Wu Edwin,
Bolson Edward L.,
Bonow Robert O.,
Sheehan Florence H.
Publication year - 2007
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.21048
Subject(s) - medicine , ventricle , cardiology , myocardial infarction , thickening , magnetic resonance imaging , cardiac function curve , infarction , nuclear medicine , radiology , heart failure , chemistry , polymer science
Objectives : The purpose of this study was to provide the first in vivo validation of a three‐dimensional (3D) method to quantify regional left ventricular (LV) function with cardiac magnetic resonance (CMR) imaging after myocardial infarction (MI). Background : Current cardiac methods to analyze LV function are limited by geometric assumptions and observer biases. Methods : MI was induced percutaneously by 90‐min proximal left circumflex artery balloon occlusion in 25 Yucatan minipigs. Cine and contrast‐enhanced (CE) CMR imaging was performed at 5 days ( n = 21) and 8 weeks ( n = 22) post‐MI. Twelve control animals without MI were also imaged. Regional wall thickening was measured orthogonal to the myocardial wall using the centersurface method. The left ventricle was divided into 16 segments (six basal 60°, six middle 60°, four apical 90°). Normal ranges for segmental wall thickness and wall thickening were defined as mean ± 2D in control hearts. Hypokinesis was defined as a segmental thickening value below the normal range. Results : Hypokinesis following MI was identified in the inferior, inferolateral and anterolateral segments when compared with controls and corresponded to areas of infarction by CE CMR. The aggregate wall thickening was also expressed as a percentage at 5 days (Infarct zone: 15% ± 16% vs. NonInfarct zone 33% ± 20%, P < 0.001) and 8 weeks (Infarct zone 20% ± 20% vs. NonInfarct zone 32% ± 22%, P < 0.001). Conclusions : The centersurface method can quantify regional wall thickening and spatially identify regions of abnormal function in 3D after MI without relying on geometric assumptions. This method may be a valuable tool to quantify regional LV function in the assessment of myocardial viability, ischemia, infarction, and the response to therapeutic interventions. © 2007 Wiley‐Liss, Inc.