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Factors predictive of cardiac events and restenosis after sirolimus‐eluting stent implantation in small coronary arteries
Author(s) -
Lee Cheol Whan,
Suh Jon,
Lee SeWhan,
Park DukWoo,
Lee SeungHwan,
Kim YoungHak,
Hong MyeongKi,
Kim JaeJoong,
Park SeongWook,
Park, SeungJung
Publication year - 2007
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.21019
Subject(s) - medicine , restenosis , cardiology , mace , stent , coronary arteries , lesion , coronary artery disease , stenosis , univariate analysis , sirolimus , myocardial infarction , radiology , artery , percutaneous coronary intervention , surgery , multivariate analysis
Objectives : Predictors of cardiac events and restenosis after sirolimus‐eluting stent (SES) implantation in small coronary arteries were evaluated.Background : Although SES implantation has markedly reduced the risk of restenosis, small vessel disease remains a major cause of SES failure.Methods : We prospectively investigated the factors predictive of cardiac events and restenosis in 1,092 consecutive patients who received SES implantation for 1,269 lesions in small coronary arteries (≤2.8 mm). Follow‐up angiography at 6 months was performed in 751 patients with 889 lesions (follow‐up rate 70.3%).Results : Restenosis (diameter stenosis ≥ 50%) was angiographically documented in 65 patients with 77 lesions (8.7%): 55 focal (71.4%), 8 diffuse (10.4%), 2 diffuse proliferative (2.6%), and 12 total (15.6%). Lesion length, stent length, reference artery size, and in‐stent restenotic lesions were univariate predictors of restenosis. By multivariate analysis, lesion length (OR 1.04; 95% CI 1.02–1.05; P < 0.001) and in‐stent restenotic lesions (OR 3.38; 95% CI 1.80–6.35; P < 0.001) were significant independent predictors of restenosis. During follow‐up (23.2 ± 7.9 months), there were 17 deaths (5 cardiac and 12 noncardiac), 5 nonfatal Q‐wave myocardial infarctions, and 42 target lesion revascularizations. The cumulative probability of survival without major adverse cardiac events (MACE) was (96.6 ± 0.6)% at 1 year and (95.1 ± 0.7)% at 2 years. In multivariate analysis, lesion length (HR 1.04; 95% CI 1.01–1.07; P = 0.004) and in‐stent restenotic lesions (HR 3.29; 95% CI 1.58–6.86; P = 0.001) were independently related to MACE.Conclusions : SES implantation in small coronary arteries is safe and effective, with lesion length having a major impact on restenosis and MACE. © 2006 Wiley‐Liss, Inc.