Premium
Diabetes mellitus does not preclude stabilization or improvement of renal function after stent revascularization in patients with kidney insufficiency and renal artery stenosis
Author(s) -
Silva Jose A.,
Potluri Srinivas,
White Christopher J.,
Collins Tyrone J.,
Jenkins J. Stephen,
Subramanian Rajesh,
Ramee Stephen R.
Publication year - 2007
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.20980
Subject(s) - medicine , renal function , stent , revascularization , renal artery , creatinine , renal artery stenosis , cardiology , diabetic nephropathy , renal artery obstruction , diabetes mellitus , kidney , surgery , urology , endocrinology , myocardial infarction
Abstract Objective : To assess the impact of stent revascularization on the renal function of diabetic and nondiabetic patients with renal insufficiency. Background : Renal artery revascularization has been shown to stabilize or improve renal function in patients with significant renal artery stenosis and impaired renal function. However, some studies have suggested negligible or no benefit of renal function in diabetic patients with the same condition. Methods : We retrospectively compared data from 50 consecutive patients undergoing renal artery stent placement with renal insufficiency (serum creatinine ≥1.5–4.0 mg/dl) and global ischemia (bilateral or solitary [single] kidney renal artery stenosis) There were 17 diabetic (DM) and 33 nondiabetic (NDM) patients. The endpoints included the follow‐up measurements of renal function, blood pressure, and number of antihypertensive medications. Results : After stent placement, at a mean follow‐up of 42 ± 18 months (range: 6–62 months), 79% NDM ( N = 26), and 76% DM patients ( N = 13) ( P = NS) had improvement in the slope of the reciprocal of creatinine (1/SCr), indicating a beneficial effect in renal function in many patients. Conclusion : Renal artery stent placement appears to be equally beneficial in preserving renal function in DM and NDM patients with ischemic nephropathy and global renal ischemia. © 2006 Wiley‐Liss, Inc.