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Histopathological findings of new in‐stent lesions developed beyond five years
Author(s) -
Hasegawa Katsuyuki,
Tamai Hideo,
Kyo Eisho,
Kosuga Kunihiko,
Ikeguchi Shigeru,
Hata Tatsuhiko,
Okada Masaharu,
Fujita Shinya,
Tsuji Takafumi,
Takeda Shinsaku,
Fukuhara Rei,
Kikuta Yuetsu,
Motohara Seiichiro,
Ono Kazuo,
Takeuchi Eiji
Publication year - 2006
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.20787
Subject(s) - medicine , stent , restenosis , conventional pci , percutaneous coronary intervention , atherectomy , radiology , lesion , bare metal , coronary angiography , bare metal stent , angiography , target lesion , surgery , cardiology , myocardial infarction , drug eluting stent
We analyzed 14 cases of new lesions inside implanted bare‐metal stents. In every case, there was no angiographic restenosis within 3 years, but a new lesion was observed inside a stented segment at long‐term follow‐up (>5 years). Fourteen cases were evaluated: 9 with Wiktor stents, 2 with Palmaz‐Schatz stents, and 3 with ACS Multilink stents. The interval from stent implantation to follow‐up angiography was 63–147 months (89 ± 23). Thirteen lesions were treated by percutaneous coronary intervention (PCI) and stenotic tissue was obtained by directional coronary atherectomy (DCA) in 10 cases. All retrieved samples were composed of newly developed atherosclerosis facing the healed neointimal layer, and four samples showed histopathological findings of acute coronary syndrome. Stent struts were retrieved in four cases and no inflammation was observed surrounding them. Qualitative and quantitative analysis of stent struts was performed in two cases that showed no metal corrosion. These findings suggest that new atherosclerotic progression occurred inside the implanted stent without peristrut inflammation. © 2006 Wiley‐Liss, Inc.