Premium
Outcome of patients with acute coronary syndromes and moderate coronary lesions undergoing deferral of revascularization based on fractional flow reserve assessment
Author(s) -
Fischer Joshua J.,
Wang XinQun,
Samady Habib,
Sarembock Ian J.,
Powers Eric R.,
Gimple Lawrence W.,
Ragosta Michael
Publication year - 2006
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.20748
Subject(s) - medicine , fractional flow reserve , cardiology , revascularization , acute coronary syndrome , deferral , hemodynamics , myocardial infarction , coronary angiography , finance , economics
Abstract Objectives : To determine the outcome of consecutive patients with and without acute coronary syndromes (ACS) in whom revascularization was deferred on the basis of fractional flow reserve (FFR). Background : FFR < 0.75 correlates with ischemia on noninvasive tests and deferral of treatment on the basis of FFR is associated with low event rates in selected populations. Whether these low event rates apply to patients undergoing assessment of moderate stenoses in association with an ACS is not known and is an important clinical question. Methods : Retrospective analysis and 12 month follow‐up of consecutive, moderate (50–70%) de novo coronary lesions assessed with FFR. Results : Revascularization was deferred in 120 lesions (111 patients) with FFR ≥ 0.75. ACS was present in 35 patients (40 lesions). The clinical, angiographic and coronary hemodynamic characteristics of patients with and without ACS were similar. Among the 35 patients with ACS, there were 3 deaths, 1 MI, and 6 target vessel revascularizations (TVRs) (15% of lesions). Among the 76 patients without ACS, there were 5 deaths, 1 MI, and 7 TVR's (9% of lesions). Conclusions : Deferral of revascularization based on FFR in patients with ACS and moderate coronary stenoses is associated with acceptable and low event rates at 1 year. © 2006 Wiley‐Liss, Inc.