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Intra‐atrial tissue plasminogen activator infusion for prosthetic valve thrombosis
Author(s) -
Seltzer Sharon M.,
Reed Michael D.,
Siwik Ernest S.
Publication year - 2006
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.20557
Subject(s) - medicine , thrombolysis , thrombosis , recombinant tissue plasminogen activator , complication , surgery , tissue plasminogen activator , heart valve , cardiology , heart disease , atrioventricular valve , plasminogen activator , myocardial infarction , ischemia , ischemic stroke , ventricle , modified rankin scale
Thrombosis is a well‐known and life‐threatening complication of prosthetic mechanical valves. Therapy typically requires medical thrombolysis or surgical thrombectomy/valve replacement. We report the case of a thrombosed atrioventricular valve in a young boy with complex congenital heart disease, which was successfully treated with direct intra‐atrial infusion of recombinant tissue plasminogen activator after failed attempts at systemic therapy. We present this treatment as an alternative to conventional medical therapy. © 2005 Wiley‐Liss, Inc.