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Transcoronary transplantation of autologous mesenchymal stem cells and endothelial progenitors into infarcted human myocardium
Author(s) -
Katritsis Demosthenes G.,
Sotiropoulou Panagiota A.,
Karvouni Evangelia,
Karabinos Ilias,
Korovesis Socrates,
Perez Sonia A.,
Voridis Eutychios M.,
Papamichail Michael
Publication year - 2005
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.20406
Subject(s) - medicine , transplantation , mesenchymal stem cell , myocardial infarction , cardiology , contractility , scars , progenitor cell , regeneration (biology) , stem cell , endothelial progenitor cell , surgery , pathology , biology , genetics , microbiology and biotechnology
The aim of the study was to investigate whether a combination of mesenchymal stem cells (MSCs) capable of differentiating into cardiac myocytes and endothelial progenitors (EPCs) that mainly promote neoangiogenesis might be able to facilitate tissue repair in myocardial scars. Previous studies have shown that intracoronary transplantation of autologous bone marrow stem cells results in improvement of contractility in infracted areas of human myocardium. Eleven patients with an anteroseptal myocardial infarction (MI) underwent transcoronary transplantation of bone marrow‐derived MSCs and EPCs to the infarcted area through the left anterior descending artery. Eleven age‐ and sex‐matched patients served as controls. Wall motion score index was significantly lower at follow‐up in the transplantation ( P = 0.04) but not in the control group. On stress echocardiography, there was improvement of myocardial contractility in one or more previously nonviable myocardial segments in 5 out of 11 patients (all with recent infarctions) and in none of the controls ( P = 0.01). Restoration of uptake of Tc 99m sestamibi in one or more previously nonviable myocardial scars was seen in 6 out of 11 patients subjected to transplantation and in none of the controls ( P = 0.02). Cell transplantation was an independent predictor of improvement of nonviable tissue. Intracoronary transplantation of MSCs and EPCs is feasible, safe, and may contribute to regional regeneration of myocardial tissue early or late following MI. © 2005 Wiley‐Liss, Inc.