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Intravascular ultrasound analysis of beta radiation therapy for diffuse in‐stent restenosis to inhibit intimal hyperplasia
Author(s) -
Hong MyeongKi,
Park SeongWook,
Moon DaeHyuk,
Oh SeungJun,
Lee Cheol Whan,
Rhee KyoungSuk,
Sun Fucheng,
Song JongMin,
Kang DukHyun,
Song JaeKwan,
Kim JaeJoong,
Park SeungJung
Publication year - 2001
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.1261
Subject(s) - medicine , restenosis , intravascular ultrasound , intimal hyperplasia , angioplasty , radiation therapy , stent , radiology , lesion , nuclear medicine , surgery , smooth muscle
We evaluated the efficacy of β‐radiation therapy ( 188 Re‐MAG 3 ) to inhibit intimal hyperplasia (IH) in diffuse in‐stent restenosis by intravascular ultrasound (IVUS) analysis in 50 patients. Nine patients who did not agree with radiation therapy, and therefore underwent rotational atherectomy and balloon angioplasty for diffuse in‐stent restenosis in the same study period, were selected for control groups. Serial IVUS comparisons were available in 44 of 50 patients with radiation therapy and 7 of 9 control patients. At 6‐month follow‐up, there was less significant increase of IH area in patients with radiation therapy than in control patients (Δ IH area = 0.1 ± 0.8 mm 2 vs. 2.6 ± 1.8 mm 2 , P > 0.001 in mean values, and 0.6 ± 1.4 mm 2 vs. 2.9 ± 2.1 mm 2 , P = 0.026 in values of follow‐up lesion site, respectively). In conclusion, β‐radiation therapy might be an effective treatment modality to inhibit intimal hyperplasia in patients with diffuse in‐stent restenosis. Cathet Cardiovasc Intervent 2001;54:169–173. © 2001 Wiley‐Liss, Inc.