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Prediction of the physiologic severity of coronary lesions using 3D IVUS: Validation by direct coronary pressure measurements
Author(s) -
Takayama Tadateru,
Hodgson John McB.
Publication year - 2001
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.1129
Subject(s) - intravascular ultrasound , fractional flow reserve , medicine , cardiology , lumen (anatomy) , coronary angiography , lesion , pressure gradient , radiology , pathology , myocardial infarction , physics , mechanics
Abstract This study was performed to determine whether three‐dimensional intravascular ultrasound (3D IVUS) could predict the physiologic significance of coronary lesions. Seventeen lesions were evaluated by means of 3D IVUS, pressure measurements, and quantitative coronary angiography. Physiologic parameters were calculated from the 3D IVUS measures using established equations and compared to values measured by pressure guidewire. IVUS minimum lumen area (MLA) correlated with fractional flow reserve (FFR; R 2 = 0.55, P = 0.003) and pressure gradient (R 2 = 0.52, P = 0.003). Lesion length (L) had a positive correlation with pressure gradient (R 2 = 0.45, P = 0.007). By multivariate analysis, the only significant independent determinant of FFR was MLA/L measured by IVUS. The IVUS‐predicted pressure gradient and FFR were well correlated with values measured directly (R 2 = 0.88, P < 0.001; R 2 = 0.90, P < 0.001, respectively). The physiologic severity of coronary lesions is primarily influenced by lumen area and lesion length and can be established by 3D IVUS. Cathet Cardiovasc Intervent 2001;53:48–55. © 2001 Wiley‐Liss, Inc.