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Lepirudin as a safe alternative for effective anticoagulation in patients with known heparin‐induced thrombocytopenia undergoing percutaneous coronary intervention: Case reports
Author(s) -
Manfredi Joseph A.,
Wall Rivers P.,
Sane David C.,
Braden Gregory A.
Publication year - 2001
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.1102
Subject(s) - medicine , lepirudin , percutaneous coronary intervention , heparin , conventional pci , heparin induced thrombocytopenia , complication , hirudin , bivalirudin , percutaneous , surgery , cardiology , anticoagulant , platelet , discovery and development of direct thrombin inhibitors , myocardial infarction , thrombin
Heparin‐induced thrombocytopenia (HIT) is a well‐documented complication of heparin anticoagulation therapy. Heparin's frequent use in the cardiovascular population poses a significant challenge for managing patients with HIT in need of percutaneous coronary intervention (PCI). We describe four patients with HIT who successfully underwent PCI without thrombotic or hemorrhagic complications while on lepirudin. Cathet Cardiovasc Intervent 2001;52:468–472. © 2001 Wiley‐Liss, Inc.