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Myocardial resistance assessed by guidewire‐based pressure‐temperature measurement: In vitro validation
Author(s) -
Aarnoudse Wilbert,
van den Berg Petra,
van de Vosse Frans,
Geven Maartje,
Rutten Marcel,
van Turnhout Mark,
Fearon William,
De Bruyne Bernard,
Pijls Nico
Publication year - 2004
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.10793
Subject(s) - medicine , cardiology , in vitro , biomedical engineering , biochemistry , chemistry
By injecting a few cubic centimeters of saline into the coronary artery and using thermodilution principles, mean transit time (T mn ) of the injectate can be calculated and is inversely proportional to coronary blood flow. Because microvascular resistance equals distal coronary pressure (P d ) divided by myocardial flow, the product P d · T mn provides an index of myocardial resistance (IMR). In this in vitro study in a physiologic model of the coronary circulation, we compared IMR to true myocardial resistance (TMR) at different degrees of myocardial resistance and at different degrees of epicardial stenosis. Absolute blood flow was varied from 42 to 203 ml/min and TMR varied from 0.39 to 1.63 dynes · sec/cm 5 . Inverse mean transit time correlated well to absolute blood flow (R 2 = 0.93). Furthermore, an excellent correlation was found between IMR and TMR (R 2 = 0.94). IMR was independent on the severity of epicardial stenosis and thus specific for myocardial resistance. Thus, using one single guidewire, both fractional flow reserve and IMR can be measured simultaneously as indexes of epicardial and microvascular disease, respectively, enabling separate assessment of both coronary arterial and microvascular disease. Catheter Cardiovasc Interv 2004; 62:56–63. © 2004 Wiley‐Liss, Inc.