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Percutaneous mitral valve repair: A feasibility study in an ovine model of acute ischemic mitral regurgitation
Author(s) -
Liddicoat John R.,
Mac Neill Briain D.,
Gillinov A. Marc,
Cohn William E.,
Chin ChiHui,
Prado Aldo D.,
Pandian Natesa G.,
Oesterle Stephen N.
Publication year - 2003
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.10662
Subject(s) - medicine , percutaneous , cardiology , mitral regurgitation , mitral valve , coronary sinus , mitral valve annuloplasty , mitral valve repair , surgery
Annuloplasty is the cornerstone of surgical mitral valve repair. A percutaneous transvenous catheter‐based approach for mitral valve repair was tested by placing a novel annuloplasty device in the coronary sinus of sheep with acute ischemic mitral regurgitation. Mitral regurgitation was reduced from 3–4+ to 0–1+ in all animals ( P < 0.03). The annuloplasty functioned by reducing septal‐lateral mitral annular diameter (30 ± 2.1 mm preinsertion vs. 24 ± 1.7 mm postinsertion; P < 0.03). These preliminary experiments demonstrate that percutaneous mitral annuloplasty is feasible. Further study is necessary to demonstrate long‐term safety and efficacy of this novel approach. Catheter Cardiovasc Interv 2003;60:410–416.© 2003 Wiley‐Liss, Inc.