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Coronary flow reserve correlates left ventricular diastolic dysfunction in patients with dilated cardiomyopathy
Author(s) -
Teragaki Masakazu,
Yanagi Shiro,
Toda Iku,
Sakamoto Kazuo,
Hirota Kazuyoshi,
Takeuchi Kazuhide,
Yoshikawa Junichi
Publication year - 2003
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.10349
Subject(s) - medicine , cardiology , dilated cardiomyopathy , coronary flow reserve , diastole , ejection fraction , cutoff , doppler echocardiography , heart failure , diastolic function , doppler effect , blood flow , blood pressure , physics , quantum mechanics , astronomy
The relationship between altered coronary circulation and left ventricular (LV) function in dilated cardiomyopathy (DCM) remains unclear. We used the Doppler guidewire and transthoracic echo Doppler in 24 DCM patients to investigate the relationship between coronary flow reserve (CFR) and LV systolic/diastolic function, trying to predict diastolic dysfunction and evaluate DCM severity with CFR. CFR correlated better with the deceleration time (DT) of the E‐wave and the ratio of E‐wave peak value to that of the A‐wave (E/A) than with LV ejection fraction (EF). The optimal CFR cutoff value for predicting the restrictive pattern of transmitral flow velocity (DT = 120 msec) was 2.6 (sensitivity 91%, specificity 100%). Dividing patients into two groups around the CFR = 2.6 cutoff, differences in DT and E/A between groups were more prominent than those for EF. CFR correlates better with LV diastolic than systolic function and may be useful for predicting diastolic dysfunction in DCM patients. Cathet Cardiovasc Intervent 2003;58:43–50. © 2003 Wiley‐Liss, Inc.