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Relation of troponin T release kinetics to long‐term clinical outcome in patients with acute ST segment elevation myocardial infarction treated with a percutaneous intervention
Author(s) -
Karavidas Apostolos J.,
Vrachatis Antony D.,
Alpert Martin A.,
Nikas Dimitris J.,
Achtypis Dionissios I.,
Masrakas Evagellas P.,
Foukarakis Masolis G.,
Fotiades Toannis N.,
Zacharoulis Apostolos A.
Publication year - 2002
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.10229
Subject(s) - medicine , percutaneous coronary intervention , cardiology , myocardial infarction , troponin , troponin i , st segment , killip class , troponin t , angioplasty , chest pain
The purpose of this study was to determine the relation of troponin T release kinetics to long‐term clinical outcome in patients with an acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention. One hundred and four patients with typical ischemic chest pain and > 1.5 mm ST segment elevation in > 2 contiguous leads underwent primary stenting (n = 60) or primary percutaneous transluminal coronary angioplasty (n = 44). Serum troponin T concentrations were obtained prior to and serially postintervention for 72 hr. Mean time to peak serum troponin T concentration was significantly longer in patients with cardiac death ( P = 0.02), reinfarction ( P = 0.007), target lesion reintervention ( P = 0.03), and the composite of these events (13.2 ± 5.3 vs. 9.3 ± 4.0 hr; P < 0.0005). Multivariate analysis identified age, Killip class > 2, and time to peak serum troponin T concentration as independent predictors of long‐term cardiac event‐free survival. Thus, time to peak serum troponin T concentration independently predicts long‐term cardiac event‐free survival in patients with acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention. Cathet Cardiovasc Intervent 2002;56:312–319. © 2002 Wiley‐Liss, Inc.