Relation of troponin T release kinetics to long‐term clinical outcome in patients with acute ST segment elevation myocardial infarction treated with a percutaneous intervention | Zendy

Karavidas Apostolos J. | Zendy; Vrachatis Antony D. | Zendy; Alpert Martin A. | Zendy; Nikas Dimitris J. | Zendy; Achtypis Dionissios I. | Zendy; Masrakas Evagellas P. | Zendy; Foukarakis Masolis G. | Zendy; Fotiades Toannis N. | Zendy; Zacharoulis Apostolos A. | Zendy

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Relation of troponin T release kinetics to long‐term clinical outcome in patients with acute ST segment elevation myocardial infarction treated with a percutaneous intervention

Author(s) -

Karavidas Apostolos J.,

Vrachatis Antony D.,

Alpert Martin A.,

Nikas Dimitris J.,

Achtypis Dionissios I.,

Masrakas Evagellas P.,

Foukarakis Masolis G.,

Fotiades Toannis N.,

Zacharoulis Apostolos A.

Publication year - 2002

Publication title -

catheterization and cardiovascular interventions

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.988

H-Index - 116

eISSN - 1522-726X

pISSN - 1522-1946

DOI - 10.1002/ccd.10229

Subject(s) - medicine , percutaneous coronary intervention , cardiology , myocardial infarction , troponin , troponin i , st segment , killip class , troponin t , angioplasty , chest pain

The purpose of this study was to determine the relation of troponin T release kinetics to long‐term clinical outcome in patients with an acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention. One hundred and four patients with typical ischemic chest pain and > 1.5 mm ST segment elevation in > 2 contiguous leads underwent primary stenting (n = 60) or primary percutaneous transluminal coronary angioplasty (n = 44). Serum troponin T concentrations were obtained prior to and serially postintervention for 72 hr. Mean time to peak serum troponin T concentration was significantly longer in patients with cardiac death ( P = 0.02), reinfarction ( P = 0.007), target lesion reintervention ( P = 0.03), and the composite of these events (13.2 ± 5.3 vs. 9.3 ± 4.0 hr; P < 0.0005). Multivariate analysis identified age, Killip class > 2, and time to peak serum troponin T concentration as independent predictors of long‐term cardiac event‐free survival. Thus, time to peak serum troponin T concentration independently predicts long‐term cardiac event‐free survival in patients with acute ST segment elevation myocardial infarction treated with a primary percutaneous intervention. Cathet Cardiovasc Intervent 2002;56:312–319. © 2002 Wiley‐Liss, Inc.

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