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Intracoronary beta‐radiation of de novo coronary lesions using a 186 Re liquid‐filled balloon system: Six‐month results from a clinical feasibility study
Author(s) -
Coussement Patrick K.,
Stella Pieter,
Vanbilloen Hubert,
Verbruggen Alfons,
van Rijk Peter,
Hoekstra A.,
Van Limbergen Erik,
de Jaegere Peter,
De Scheerder Ivan
Publication year - 2002
Publication title -
catheterization and cardiovascular interventions
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.988
H-Index - 116
eISSN - 1522-726X
pISSN - 1522-1946
DOI - 10.1002/ccd.10043
Subject(s) - medicine , restenosis , angioplasty , balloon , brachytherapy , target lesion , lesion , radiology , radiation therapy , stent , surgery , myocardial infarction , cardiology , percutaneous coronary intervention
Vascular brachytherapy has shown to be effective for in‐stent restenosis, but efficacy in de novo lesions remains uncertain. We evaluated feasibility and outcome of intracoronary beta‐radiation therapy in de novo coronary lesions using a 186 Re liquid‐filled balloon system. Thirty‐three patients received 20 Gy 186 Re beta‐radiation immediately after balloon angioplasty. The 6‐month restenosis rate was 41% (12/29) and restenosis was located within the target lesion in eight patients and at the edges of the injured and irradiated segment, outside the target lesion, in four patients. At 6 months, four patients (12%), all stented during the initial procedure, had experienced a late (> 30 days) total occlusion. Intracoronary beta‐radiation therapy of de novo coronary lesions using 186 Re is technically feasible. No reduction in restenosis was observed. The high incidence of late total occlusions may have been prevented by avoiding new stent implantation and prolonging double antiplatelet therapy. Cathet Cardiovasc Intervent 2002;55:28–36. © 2002 Wiley‐Liss, Inc.