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Dysregulation of the immune response in coronavirus disease 2019
Author(s) -
Mohamed Khosroshahi Leila,
Rezaei Nima
Publication year - 2021
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.11517
Subject(s) - cytokine storm , ards , immunology , immune system , medicine , coronavirus , immune dysregulation , disease , cytokine , lymphocyte , monocyte , covid-19 , pandemic , macrophage activation syndrome , lung , infectious disease (medical specialty) , arthritis
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can trigger a cytokine storm in the pulmonary tissue by releasing various types of mediators, leading to acute respiratory distress syndrome (ARDS). Increased neutrophil‐to‐lymphocyte ratio, as well as CD4+ T lymphopenia, is reported in cases with novel coronavirus disease (COVID‐19), meanwhile, lymphopenia is a significant finding in the majority of COVID‐19 cases with a severe phenotype. Moreover, excessive activation of monocyte/macrophage and cytokine storms are associated with the severity of the disease and the related complications in SARS‐CoV‐2 infection. Understanding the immune response dysregulation in COVID‐19 is essential to develop more effective diagnostic, therapeutic, and prophylactic strategies in this pandemic.