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ACTA2‐AS1 suppresses lung adenocarcinoma progression via sequestering miR‐378a‐3p and miR‐4428 to elevate SOX7 expression
Author(s) -
Ying Kangtai,
Wang Ling,
Long Guangyan,
Lian Chan,
Chen Zhe,
Lin Wei
Publication year - 2020
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.11451
Subject(s) - cancer research , microrna , biology , adenocarcinoma , suppressor , gene silencing , competing endogenous rna , cell growth , lung cancer , antisense rna , rna , cell , long non coding rna , cancer , pathology , gene , medicine , biochemistry , genetics
Lung adenocarcinoma (LUAD) is the most common histological subtype of lung cancer. The abnormal expression of long noncoding RNAs (lncRNAs) can facilitate or suppress the development of malignant tumors. lncRNA actin alpha 2, smooth muscle antisense RNA 1 (ACTA2‐AS1) has been reported to function as a tumor suppressor in liver cancer, nevertheless, its influences on LUAD remain to be investigated. In this paper, ACTA2‐AS1 was identified as a downregulated lncRNA in LUAD samples and cells. Functionally, ACTA2‐AS1 overexpression restrained cell proliferation but accelerated cell apoptosis in LUAD. In addition, we determined the suppressive effect of ACTA2‐AS1 on LUAD cell invasion, migration, and epithelial–mesenchymal transition progress. Mechanistically, ACTA2‐AS1 exert functions as a competing endogenous RNA through serving as a sponge for microRNA‐378a‐3p (miR‐378a‐3p) and microRNA‐4428 (miR‐4428) to elevate SRY‐related high‐mobility group box 7 (SOX7) expression. Importantly, SOX7 silencing could recover the ACTA2‐AS1‐mediated cell functions. To summarize, ACTA2‐AS1 suppresses the malignant processes of LUAD cells through sequestering miR‐378a‐3p and miR‐4428 to augment SOX7 expression.