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The highly interrelated GHRH, p53, and Hsp90 universe
Author(s) -
Barabutis Nektarios,
Siejka Agnieszka
Publication year - 2020
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.11356
Subject(s) - disease , universe , acute respiratory distress , cognitive science , neuroscience , biology , medicine , psychology , physics , astrophysics , lung
p53 universe is composed of a complex regulatory network, destined to counteract multifarious challenges threatening cell survival. Imbalance in those responses may result in human disease associated with inevitable consequences. The present work delivers our view of the corresponding phenomena, by involving the endothelium defender in meticulously orchestrated events against inflammatory stimuli. Immersing into the great depths of p53 cosmos may lead to promising therapies against devastating disorders, including acute respiratory distress syndrome.