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Role of autophagy in inhibiting the proliferation of A549 cells by type III interferon
Author(s) -
Gao Dongmei,
Yu Xiaoqin,
Zhang Bo,
Kong Min,
Fang Yong,
Cai Yu,
Zhu Chengchu,
Zhao Jun,
Li Jicheng
Publication year - 2019
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.11132
Subject(s) - autophagy , interferon , a549 cell , apoptosis , cell growth , cancer research , biology , microbiology and biotechnology , small interfering rna , gene , immunology , rna , genetics
Interferons (IFNs) have anti‐viral and anti‐tumour effects. Type III interferon, as a member of the recently discovered interferon family, has been proved to inhibit tumour proliferation and promote the apoptosis of various tumour cells. However, whether type III IFN could inhibit the proliferation of lung cancer was not clear. In this study, we found that interferon λ (IFN λ) could inhibit the proliferation of A549 cells and induce autophagy and apoptosis of A549 cells. IFN λ could promote the expression of autophagy gene Beclin1 and interfere the expression of autophagy gene Beclin1 with small interfering RNA, thus inhibiting the effect of type III interferon on anti‐proliferation and promoting apoptosis of lung cancer cell. These results suggested that IFN λ could inhibit the proliferation of A549 cells by activating autophagy pathway, and IFN λ might be one of the potential therapeutic drugs for lung cancer.