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Role of NCoR1 in mitochondrial function and energy metabolism
Author(s) -
Lima Tanes I.,
Valentim Rafael R.,
Araújo Hygor N.,
Oliveira André G.,
Favero Bianca C.,
Menezes Eveline S.,
Araújo Rafaela,
Silveira Leonardo R.
Publication year - 2018
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10973
Subject(s) - corepressor , biology , mitochondrion , microbiology and biotechnology , energy homeostasis , function (biology) , transcriptional regulation , cell metabolism , transcription factor , gene , genetics , cell , nuclear receptor , receptor
Mitochondrial number and shape are constantly changing in response to increased energy demands. The ability to synchronize mitochondrial pathways to respond to energy fluctuations within the cell is a central aspect of mammalian homeostasis. This dynamic process depends on the coordinated activation of transcriptional complexes to promote the expression of genes encoding for mitochondrial proteins. Recent evidence has shown that the nuclear corepressor NCoR1 is an essential metabolic switch which acts on oxidative metabolism signaling. Here, we provide an overview of the emerging role of NCoR1 in the transcriptional control of energy metabolism. The identification and characterization of NCoR1 as a central, evolutionary conserved player in mitochondrial function have revealed a novel layer of metabolic control. Defining the precise mechanisms by which NCoR1 acts on energy homeostasis will ultimately contribute towards the development of novel therapies for the treatment of metabolic diseases such as obesity and type 2 diabetes.