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Biological effects of trans fatty acids and their possible roles in the lipid rafts in apoptosis regulation
Author(s) -
Qiu Bin,
Wang Qing,
Liu Wei,
Xu TongCheng,
Liu LiNa,
Zong AiZhen,
Jia Min,
Li Jing,
Du FangLing
Publication year - 2018
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10958
Subject(s) - lipid raft , apoptosis , immune system , lipid signaling , coronary heart disease , inflammation , biology , microbiology and biotechnology , biochemistry , medicine , signal transduction , immunology
A large number of recent studies are focused on evaluating the mechanism of action of trans fatty acids (TFAs) on the progression of apoptosis. A strong positive association has been reported between TFA and coronary heart disease (CHD), obesity and nonalcoholic steatohepatitis and so on. The present study reviewed the biological effects of trans fatty acids (TFA) and their possible roles in lipid rafts in regulating apoptosis. The following aspects of TFA were included: the research about TFA and diseases affecting serum lipid levels, inducing system inflammation and immune response, and the correlation between TFA and apoptosis. The primary purpose of the review article was to comprehensively evaluate the potential correlation between lipid rafts and apoptosis induced by different structures of TFA and provide some new research progress and future directions about it.