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Mitoimmunity—when mitochondria dictates macrophage function
Author(s) -
CorrêadaSilva Felipe,
Pereira Jéssica A. S.,
de Aguiar Cristhiane F.,
de MoraesVieira Pedro M. M.
Publication year - 2018
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10921
Subject(s) - mitochondrion , microbiology and biotechnology , macrophage , proinflammatory cytokine , inflammasome , reactive oxygen species , biology , glycolysis , mitochondrial ros , secretion , function (biology) , citric acid cycle , chemistry , metabolism , inflammation , biochemistry , immunology , in vitro
In the past decade, several reports have appointed the importance of mitochondria in the immune response. Our understanding of mitochondria evolved from a simple supplier of energy into a platform necessary for immunorregulation. Proinflammatory responses are associated with enhanced glycolytic activity and breakdown of the TCA cycle. Mitochondrial reactive species of oxygen (mROS) are key regulators of classically activated macrophages, with substantial impact in the anti‐microbicidal activity and pro‐inflammatory cytokine secretion of macrophages. The inflammasome activation in macrophages is dependent on mROS production and mitochondrial regulation and mitochondrial dynamics and functionality direct impact inflammatory responses. Alternative activated macrophage metabolism relies on fatty acid oxidation, and the mechanism responsible for this phenotype is not fully elucidated. Thus, cellular metabolism and mitochondria function is a key immunoregulatory feature of macrophage biology. In this review, we will provide insights into recently reported evidences of mitochondria‐related metabolic nodes, which are important for macrophage physiology.