Premium
Mechanisms of AMPK in the maintenance of ATP balance during energy metabolism
Author(s) -
Ke Rong,
Xu Qicao,
Li Cong,
Luo Lingyu,
Huang Deqiang
Publication year - 2018
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10915
Subject(s) - ampk , amp activated protein kinase , oxidative phosphorylation , autophagy , protein kinase a , beta oxidation , biochemistry , metabolism , chemistry , microbiology and biotechnology , adenosine triphosphate , fatty acid synthesis , lipid metabolism , biology , fatty acid , phosphorylation , apoptosis
AMP‐activated protein kinase (AMPK) is a conserved sensor of cellular energy change and is activated by increased AMP/ATP and/or ADP/ATP ratios. AMPK maintains the energy balance by decreasing the ATP‐consuming processes such as transcription of synthetic fat genes and rRNA, the translation of ribosomal proteins, synthesis of cholesterol and fatty acid, while the metabolic pathways such as glucose and fatty transport, fatty acid oxidation, autophagy, mitochondrial synthesis and oxidative metabolism are increased to preserve ATP during energy deficiency. Recent advance has demonstrated that AMPK activity has a close association with the initiation and progression in various cancers. Here we review the mechanisms that AMPK controls energy metabolism through regulating ATP synthesis and consumption, and further discuss the deregulation of AMPK in cancers.