Premium
Intermediate filaments and cellular mechanics
Author(s) -
Goldmann Wolfgang H.
Publication year - 2018
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10879
Subject(s) - filamin , plectin , intermediate filament , desmin , cytoskeleton , actin , lamin , microtubule , intermediate filament protein , myosin , protein filament , biophysics , microbiology and biotechnology , chemistry , actinin , microfilament , biology , biochemistry , vimentin , cell , immunohistochemistry , nucleus , immunology
Intermediate filaments (IFs) are one of the three types of cytoskeletal polymers that resist tensile and compressive forces in cells. They crosslink each other as well as with actin filaments and microtubules by proteins, which include desmin, filamin C, plectin, and lamin (A/C). Mutations in these proteins can lead to a wide range of pathologies, some of which exhibit mechanical failure of the skin, skeletal, or heart muscle.