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Vitamin D enhances omega‐3 polyunsaturated fatty acids‐induced apoptosis in breast cancer cells
Author(s) -
Yang Jing,
Zhu Shenglong,
Lin Guangxiao,
Song Ci,
He Zhao
Publication year - 2017
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10806
Subject(s) - apoptosis , breast cancer , polyunsaturated fatty acid , cancer research , carcinogenesis , vitamin d and neurology , chemistry , endocrinology , cancer , medicine , biology , biochemistry , fatty acid
Breast cancer is a leading type of cancer in women and generally classified into three subtypes of ER + /PR + , HER2 + and triple negative. Both omega‐3 polyunsaturated fatty acids and vitamin D 3 play positive role in the reduction of breast cancer incidence. However, whether combination of omega‐3 polyunsaturated fatty acids and vitamin D 3 has stronger protective effect on breast carcinogenesis still remains unknown. In this study, we show that the combination of ω‐3 free fatty acids (ω‐3 FFAs) and 1α, 25‐dihydroxy‐vitamin D 3 (VD 3 ) dramatically enhances cell apoptosis among three subtypes of breast cancer cell lines. Bcl‐2 and total PARP protein levels are decreased in combined treatment MCF‐7 and SK‐BR‐3 cells. Caspase signals play a vital role in cell apoptosis induced by combination. Moreover, Raf‐MAPK signaling pathway is involved in the apoptosis induction by combination of ω‐3 FFAs+VD 3 . These results demonstrate that the induction of cell apoptosis by combined treatment is dependent on different signaling pathways in three subtypes of breast cancer cell lines.

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