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Insulin‐like growth factor binding protein‐4 inhibits cell growth, migration and invasion, and downregulates COX‐2 expression in A549 lung cancer cells
Author(s) -
Li Weiwen,
Sun Debin,
Lv Zhuqing,
Wei Yueqiu,
Zheng Liyun,
Zeng Tingting,
Zhao Jialu
Publication year - 2017
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10732
Subject(s) - insulin like growth factor , a549 cell , cancer research , insulin like growth factor binding protein , growth factor , lung cancer , microbiology and biotechnology , protein expression , cell growth , cancer , chemistry , biology , medicine , biochemistry , receptor , gene
Insulin‐like growth factor binding protein 4 (IGFBP‐4) and cyclooxygenase2 (COX‐2) are associated with tumor inflammatory microenvironment which is involved in the progression of tumor. However, it is unclear that the roles of IGFBP‐4 in lung cancer and the effects of IGFBP‐4 on COX‐2 expression. In this study, we showed that IGFBP‐4 could decrease COX‐2 production in lung cancer A549 cells. IGFBP‐4 expression was significantly lower but COX‐2 expression was higher in lung cancer tissues compared to matched adjacent normal tissues. In addition, IGFBP‐4 could inhibit lung cancer cell proliferation, migration and invasion, and suppress the phosphorylation of PI3 K/AKT, ERK, and CREB. These results indicate that IGFBP‐4 has potent antitumor effects in non‐small cell lung cancer cells.