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CXCR4 and CCR7: Two eligible targets in targeted cancer therapy
Author(s) -
Mishan Mohammad Amir,
Ahmadiankia Naghmeh,
Bahrami Ahmad Reza
Publication year - 2016
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10631
Subject(s) - cxcr4 , targeted therapy , chemokine receptor , radiation therapy , cancer , medicine , cancer therapy , metastasis , chemokine , oncology , cancer research , bioinformatics , receptor , biology
Cancer is one of the most common cause of death in the world with high negative emotional, economic, and social impacts. Conventional therapeutic methods, including chemotherapy and radiotherapy, have not proven satisfactory and relapse is common in most cases. Recent studies have focused on targeted therapy with more precise identification and targeted attacks to the cancer cells. For this purpose, chemokine receptors are proper targets and among them, CXCR4 and CCR7, with a crucial role in cancer metastasis, are being considered as desired candidates for investigation. In this review paper, the most important experimental results are highlighted on the potential targeted therapies based on CXCR4 and CCR7 chemokine receptors.