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Mechanical properties study of SW480 cells based on AFM
Author(s) -
Liu Xiaogang,
Song Zhengxun,
Qu Yingmin,
Wang Guoliang,
Wang Zuobin
Publication year - 2015
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10482
Subject(s) - indentation , atomic force microscopy , nanoindentation , materials science , modulus , biomedicine , elastic modulus , nanotechnology , composite material , bioinformatics , biology
Since the invention of the atomic force microscope (AFM), it has been widely applied in biomedicine. One of the most important applications is used as an indenter tool to do the indentation experiment in order to get the mechanical properties of cells. In this paper, SW480 cells were used as the test subjects. Through the analysis of the contact and indentation, Young's modulus ( E ), which is an important parameter of cancer cells, has been estimated. Experimental results show that different mechanical models should be chosen to calculate the E in different indentation depths. Here, the E of SW480 cells was (2.5 ± 0.8) KPa at the indentation depth of 99 nm.