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Bmi‐1 regulates the migration and invasion of glioma cells through p16
Author(s) -
Liang Jun,
Wang Peng,
Xie Shao,
Wang Weifeng,
Zhou Xiuping,
Hu Jinxia,
Shi Qiong,
Zhang Xianli,
Yu Rutong
Publication year - 2015
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10390
Subject(s) - glioma , cancer research , biology , microbiology and biotechnology
Bmi‐1 is involved in the development of several human cancers; however, its significance in glioma progression remains largely unknown. We report that downregulation of Bmi‐1 clearly reduces glioma cell migration and invasion. Downregulation of Bmi‐1 promotes the expression of the tumor suppressor p16, which is important in glioma cell motility. Reduction in glioma cell invasion due to downregulation of Bmi‐1 could be rescued by p16 downregulation. These results show that Bmi‐1 contributes to the motility of glioma cells by regulating the expression of p16.