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Strategies to improve homing of mesenchymal stem cells for greater efficacy in stem cell therapy
Author(s) -
NaderiMeshkin Hojjat,
Bahrami Ahmad Reza,
Bidkhori Hamid Reza,
Mirahmadi Mahdi,
Ahmadiankia Naghmeh
Publication year - 2015
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10378
Subject(s) - homing (biology) , stem cell , progenitor cell , mesenchymal stem cell , chemokine receptor , chemokine , microbiology and biotechnology , biology , stem cell therapy , immunology , cancer research , inflammation , ecology
Stem/progenitor cell‐based therapeutic approach in clinical practice has been an elusive dream in medical sciences, and improvement of stem cell homing is one of major challenges in cell therapy programs. Stem/progenitor cells have a homing response to injured tissues/organs, mediated by interactions of chemokine receptors expressed on the cells and chemokines secreted by the injured tissue. For improvement of directed homing of the cells, many techniques have been developed either to engineer stem/progenitor cells with higher amount of chemokine receptors (stem cell‐based strategies) or to modulate the target tissues to release higher level of the corresponding chemokines (target tissue‐based strategies). This review discusses both of these strategies involved in the improvement of stem cell homing focusing on mesenchymal stem cells as most frequent studied model in cellular therapies.