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Roles of resolvins in the resolution of acute inflammation
Author(s) -
Qu Qing,
Xuan Wenjuan,
Fan GuoHuang
Publication year - 2015
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10345
Subject(s) - inflammation , lipid signaling , inflammatory response , endogeny , biology , immunology , computational biology , neuroscience , bioinformatics , medicine , biochemistry
Resolution is an active process that terminates inflammatory response to maintain health. Acute inflammation and its timely resolution are important in host response to danger signals. Unresolved inflammation is associated with widely recurrent diseases. Resolvins, including the D and E series, are endogenous lipid mediators generated during the resolution phase of acute of inflammation from the ω‐3 PUFAs, DHA, and EPA. They have anti‐inflammatory and pro‐resolving properties that have been determined in many inflammation studies in animal models. In this review, we provide an updated overview of biosynthesis, actions, and signaling pathways of resolvins, thereby underscoring their diverse protective roles and introducing novel therapeutic strategies for inflammation‐associated diseases.