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Coating of electrospun poly(lactic‐co‐glycolic acid) nanofibers with willemite bioceramic: improvement of bone reconstruction in rat model
Author(s) -
Jamshidi Adegani Fatemeh,
Langroudi Lida,
Ardeshirylajimi Abdolreza,
Dinarvand Peyman,
Dodel Masumeh,
Doostmohammadi Ali,
Rahimian Ali,
Zohrabi Parastoo,
Seyedjafari Ehsan,
Soleimani Masoud
Publication year - 2014
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10318
Subject(s) - bioceramic , plga , materials science , nanofiber , biomedical engineering , apatite , glycolic acid , electrospinning , nanoparticle , nanotechnology , composite material , chemistry , lactic acid , mineralogy , medicine , polymer , biology , bacteria , genetics
We have investigated the combination effects of bioceramics and poly(lactide‐co‐glycolide) (PLGA) on bone reconstruction in calvarial critical size defects using a rat model. Willemite (Zn 2 SiO 4 ) ceramics were prepared and coated on the surface of electrospun fabricated scaffolds. After scaffolds and nanoparticles characterization, osteoconductivity of the construct was analyzed using digital mammography, multislice spiral‐computed tomography (MSCT) imaging, and histological analysis. Eight weeks after implantation, no sign of inflammation was observed at the site of the osseous defect. The results showed that the ceramics supported bone regeneration and highest bone reconstruction were observed in willemite‐coated PLGA. This suggests that electrospun PLGA nanofibers coated with BG are potential candidate implants for bone tissue engineering applications.