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The perivascular niche governs an autoregulatory network to support breast cancer metastasis
Author(s) -
Fazilaty Hassan,
Behnam Babak
Publication year - 2014
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10261
Subject(s) - metastasis , breast cancer , niche , cancer metastasis , cancer stem cell , breast cancer metastasis , cancer cell , cancer , stem cell , neuroscience , cancer research , biology , medicine , microbiology and biotechnology , ecology
Unravelling the autoregulatory network that induces and maintains cancer stem cell state may provide novel effective therapies against breast cancer metastasis. The perivascular niche develops elements that initiate the autoregulatory machine to induce and maintain cancer stem cells, but not EMT, among newly arrived tumour cells. Inhibition of one or more primary key elements that trigger this circuit may result in the prevention or cure of breast cancer metastasis.