Premium
Lack of appreciation of the role of osmotically unresponsive water in cell volume regulation
Author(s) -
Cameron Ivan L.,
Fullerton Gary D.
Publication year - 2014
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10238
Subject(s) - cell , osmosis , osmotic shock , volume (thermodynamics) , microbiology and biotechnology , chemistry , biophysics , biology , biochemistry , membrane , thermodynamics , physics , gene
Abstract The osmotic responsiveness of cell water has been re‐evaluated of reports on the osmotic behaviour of cells. In seven animal cell types, the osmotically unresponsive water (OUR) fraction values ranged from 0.75 to 2.41 g water/g dry mass (g/g), and from 25 to 92% of the total cell water. Protein confirmation, aggregation and crowding play a major, but under‐recognised, role in determining the extent of OUR and the regulation of cell volume. Volume regulation studies that do not take into account the role of OUR must be judged incomplete.