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Functionalisation and surface modification of electrospun polylactic acid scaffold for tissue engineering
Author(s) -
Hoveizi Elham,
Nabiuni Mohammad,
Parivar Kazem,
RajabiZeleti Sareh,
Tavakol Shima
Publication year - 2014
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10178
Subject(s) - gelatin , polylactic acid , scaffold , electrospinning , biocompatibility , nanofiber , tissue engineering , materials science , surface modification , chitosan , biomedical engineering , fibroblast , adhesion , fourier transform infrared spectroscopy , chemical engineering , polymer chemistry , polymer , nanotechnology , chemistry , composite material , organic chemistry , biochemistry , in vitro , medicine , engineering , metallurgy
Repair or replacement of damaged tissues using tissue engineering technology is considered to be a fine solution for enhanced treatment of different diseases such as skin diseases. Although the nanofibers made of synthetic degradable polymers, such as polylactic acid (PLA), have been widely used in the medical field, they do not favour cellular adhesion and proliferation. To enhance cell adherence on scaffold and improve biocompatibility, the surface of PLA scaffold was modified by gelatin in our experiments. For electrospinning, PLA and gelatin were dissolved in hexafluoroisopropanol (HFIP) solvent at varying compositions (PLA:gelatin at 3:7 and 7:3). The properties of the blending nanofiber scaffold were investigated by Fourier transform infrared (FT‐IR) spectroscopy and scanning electron microscopy (SEM). Modified PLA/gelatin 7/3 scaffold is more suitable for fibroblasts attachment and viability than the PLA or gelatin nanofiber alone. Thus fibroblast cultured on PLA/gelatin scaffold could be an alternative way to improve skin wound healing.