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Kaempferol inhibits cancer cell growth by antagonizing estrogen‐related receptor α and γ activities
Author(s) -
Wang Haibin,
Gao Minghui,
Wang Junjian
Publication year - 2013
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10152
Subject(s) - kaempferol , estrogen receptor , receptor , cell growth , biology , cancer cell , estrogen receptor alpha , selective estrogen receptor modulator , microbiology and biotechnology , chemistry , cancer research , pharmacology , cancer , flavonoid , breast cancer , biochemistry , genetics , antioxidant
Kaempferol is a dietary flavonoid that can function as a selective estrogen receptor modulator (SERM). Estrogen‐related receptors alpha and gamma (ERRα and ERRγ) are orphan nuclear receptors that play important roles in mitochondrial biogenesis and cancer development. We have shown that kaempferol can functionally antagonize the activities of ERRs based on both response element reporter systems and target gene analysis. Kaempferol modulation of mitochondrial function and suppression cancer cell growth has been confirmed. These findings suggest that kaempferol may exert their anti‐cancer activities through antagonizing ERRs activities.