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Silencing Cofilin‐1 blocks PDGF ‐induced proliferation in eutopic endometrium of endometriosis patients
Author(s) -
Wang DanBo,
Xu YanLi,
Chen Peng,
Chen YingHan,
Li Yan
Publication year - 2013
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10093
Subject(s) - platelet derived growth factor receptor , gene silencing , growth factor , microbiology and biotechnology , cancer research , chemistry , cell growth , stromal cell , biology , receptor , biochemistry , gene
Platelet‐derived growth factor (PDGF) is well known to induce proliferation in variety of cells. The aim of this study was to investigate whether there is a correlation between the expression of Cofilin‐1 (CFL1) and the proliferation of eutopic endometrium stromal cells (ESC) in response to PDGF stimulation. Results show that PDGF induced the expression of CFL1 in ESC and promoted proliferation of ESC significantly in a time‐ or dose‐dependent manner. After silencing CFL1, the effect of PDGF on promoting ESC proliferation was significantly decreased. These data demonstrate that PDGF can induce CFL1 expression in ESC. Silencing CFL1 blocks PDGF‐induced proliferation in ESC.