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Vinculin, cell mechanics and tumour cell invasion
Author(s) -
Goldmann Wolfgang H.,
Auernheimer Vera,
Thievessen Ingo,
Fabry Ben
Publication year - 2013
Publication title -
cell biology international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.932
H-Index - 77
eISSN - 1095-8355
pISSN - 1065-6995
DOI - 10.1002/cbin.10064
Subject(s) - vinculin , focal adhesion , cell mechanics , microbiology and biotechnology , contractility , cell adhesion , motility , cell migration , adhesion , cell , mechanotransduction , biology , chemistry , cytoskeleton , signal transduction , biochemistry , endocrinology , organic chemistry
The focal adhesion protein, vinculin, is important for transmitting mechanical forces and orchestrating mechanical signalling events. Deregulation of vinculin results in altered cell adhesion, contractility, motility and growth, all of which are important processes in cancer metastasis. This review summarises recent reports on the role of vinculin in cellular force generation and signalling, and discusses implications for a role of vinculin in promoting cancer cell migration in 3D environments.