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Front Cover: Engineering of a Thermostable Biocatalyst for the Synthesis of 2‐ O ‐Glucosylglycerol (ChemBioChem 18/2021)
Author(s) -
Franceus Jorick,
Ubiparip Zorica,
Beerens Koen,
Desmet Tom
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202100273
Subject(s) - thermostability , protein engineering , biocatalysis , chemistry , ingredient , directed evolution , cosmetics , biochemistry , osmolyte , enzyme , combinatorial chemistry , organic chemistry , catalysis , food science , ionic liquid , mutant , gene
Enzyme engineering for the synthesis of a cosmetic ingredient : The osmolyte 2‐ O ‐glucosylglycerol is widely applied as a bioactive moisturizing ingredient in cosmetics and personal‐care products. It is produced on an industrial scale by exploiting the promiscuous transglycosylation activity of a sucrose phosphorylase, but the enzyme currently used suffers from poor thermostability. A homologous sucrose phosphorylase that is far more thermostable was engineered to drastically improve its catalytic performance for the synthesis of 2‐ O ‐glucosylglycerol, enabling the production of this compound at elevated temperatures. More information can be found in the Full Paper by T. Desmet et al.