Methemoglobin‐Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy | Zendy

Yamada Taiga | Zendy; Komatsu Teruyuki | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Premium

Methemoglobin‐Albumin Cluster Incorporating Protoporphyrin IX: Dual Functional Protein Drug for Photodynamic Therapy

Author(s) -

Yamada Taiga,

Komatsu Teruyuki

Publication year - 2021

Publication title -

chembiochem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.05

H-Index - 126

eISSN - 1439-7633

pISSN - 1439-4227

DOI - 10.1002/cbic.202100213

Subject(s) - methemoglobin , protoporphyrin ix , photosensitizer , photodynamic therapy , chemistry , heme , protoporphyrin , hemoglobin , photochemistry , biochemistry , combinatorial chemistry , biophysics , porphyrin , enzyme , organic chemistry , biology

We describe the synthesis, photophysical properties, and photodynamic activity of a methemoglobin (metHb) wrapped covalently by human serum albumins (HSAs) incorporating protoporphyrin IX (PPIX): a metHb‐HSA 3 ‐PPIX 2 cluster. The metHb core catalyzes H 2 O 2 disproportionation to generate O 2 in tumor tissue. The HSA 3 ‐PPIX 2 shell acts as a photosensitizer for 1 O 2 formation. The metHb‐HSA 3 ‐PPIX 2 cluster acts as a dual functional protein drug for photodynamic therapy.

This content is not available in your region!

Continue researching here.

Having issues? You can contact us here

Accelerating Research