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A Novel D‐A‐D Photosensitizer for Efficient NIR Imaging and Photodynamic Therapy
Author(s) -
Liu Yuhan,
Chen MiaoMiao,
Zhao Yanliang,
Lv Shibo,
Zheng Daoyuan,
Liu Dapeng,
Song Fengling
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202100107
Subject(s) - photodynamic therapy , photosensitizer , singlet oxygen , reactive oxygen species , biocompatible material , chemistry , nanotechnology , materials science , photochemistry , biomedical engineering , oxygen , medicine , biochemistry , organic chemistry
Photodynamic therapy (PDT) has attracted great interest in cancer theranostics owing to its minimal invasiveness and low side effect. In PDT, photosensitizers are indispensable components that generate cytotoxic reactive oxygen species (ROS). Tremendous efforts have been devoted to optimizing the photosensitizer with enhanced ROS efficiency. However, to improve the precision and controllability for PDT, developing NIR imaging‐guided photosensitizers are still urgent and challenging. Here, we have designed a novel photosensitizer 2Cz‐BTZ which integrated with intense NIR emission and photoinduced singlet oxygen 1 O 2 generation capabilities. Moreover, after loading the photosensitizers 2Cz‐BTZ into biocompatible amphiphilic polymers F127, the formed 2Cz‐BTZ@F127 nanoparticles (NPs) exhibited good photoinduced therapy as well as long‐term in vivo imaging capabilities. Under these merits, the 2Cz‐BTZ@F127 NPs showed NIR imaging‐guided PDT, which paves a promising way for spatiotemporally precise tumor theranostics.