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Front Cover: Stepwise Strategy for One‐Pot Synthesis of Single‐Stranded DNA Rings from Multiple Short Fragments (6/2021)
Author(s) -
Sui Zhe,
An Ran,
Komiyama Makoto,
Liang Xingguo
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202100082
Subject(s) - front cover , yield (engineering) , cover (algebra) , molecule , dna , chemistry , combinatorial chemistry , nanotechnology , product (mathematics) , stereochemistry , mathematics , materials science , engineering , organic chemistry , mechanical engineering , geometry , biochemistry , composite material
Multicomponent products are assembled step by step : When more than three kinds of parts are used to prepare thousands of big molecules with a specific structure, the procedure has to be carefully designed. For example, when ligating ssDNA strands to a long circular ssDNA, each group should contain only two or three stands to give a high yield. This rule has to be obeyed until the final product is obtained, otherwise, the materials will be used up before it is ready. This design is suitable for preparing any other complex molecule. More information can be found in the full paper by X. G. Liang et al.