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Front Cover: Repressor‐Like On‐Off Regulation of Protein Expression by the DNA‐Binding Transcription Activator‐Like Effector in T7 Promoter‐Based Cell‐Free Protein Synthesis (5/2021)
Author(s) -
Sakono Masafumi,
Hayakawa Ryoto
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202100060
Subject(s) - effector , repressor , transcription (linguistics) , t7 rna polymerase , dna , activator (genetics) , microbiology and biotechnology , biology , nuclease , promoter , transcription factor , chemistry , gene expression , genetics , gene , linguistics , philosophy , escherichia coli , bacteriophage
Like a snake glaring at a mouse climbing up ivy : The front cover picture shows the regulation of a T7 promoter system by the formation of complexes of transcription activator‐like effector nuclease (TALE) and target DNA. Protein synthesis can be switched on/off, and TALE acts as an RNA polymerase (RNAP) regulator that functions as a repressor. More information can be found in the full paper by M. Sakono and R. Hayakawa.