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Recent Advances of DNA Tetrahedra for Therapeutic Delivery and Biosensing
Author(s) -
Copp William,
Pontarelli Alexander,
Wilds Christopher J.
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000835
Subject(s) - nucleic acid , oligonucleotide , nanotechnology , dna , endocytosis , computational biology , transfection , biosensor , drug delivery , chemistry , biology , biophysics , cell , materials science , biochemistry , gene
The chemical and self‐assembly properties of nucleic acids make them ideal for the construction of discrete structures and stimuli‐responsive devices for a diverse array of applications. Amongst the various three‐dimensional assemblies, DNA tetrahedra are of particular interest, as these structures have been shown to be readily taken up by the cell, by the process of caveolin‐mediated endocytosis, without the need for transfection agents. Moreover, these structures can be readily modified with a diverse range of pendant groups to confer greater functionality. This minireview highlights recent advances related to applications of this interesting DNA structure including the delivery of therapeutic agents ranging from small molecules to oligonucleotides in addition to its use for sensing and imaging various species within the cell.