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Front Cover: Cyclotide Structures Revealed by NMR, with a Little Help from X‐ray Crystallography (ChemBioChem 24/2020)
Author(s) -
Handley Thomas N. G.,
Wang Conan K.,
Harvey Peta J.,
Lawrence Nicole,
Craik David J.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000778
Subject(s) - nuclear magnetic resonance spectroscopy , front cover , chemistry , cyclic peptide , peptide , two dimensional nuclear magnetic resonance spectroscopy , crystallography , disulfide bond , stereochemistry , cover (algebra) , biochemistry , mechanical engineering , engineering
Cyclotides are a fascinating class of macrocyclic plant peptides that contain a cyclic cystine knot, a compact and highly stable structural motif. This review by D. J. Craik and co‐authors is an historical overview of the developments in NMR spectroscopy, as well as X‐ray crystallography, that have enabled the resolution of cyclotide structures and conclusive determination of disulfide connectivities of several exemplar cyclotides. Such work has been inspired by the innovative and pioneering studies of Professor Horst Kessler in cyclic peptide chemistry and NMR spectroscopy. Cover art by P.J.H.