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Front Cover: Peptidyl Acyloxymethyl Ketones as Activity‐Based Probes for the Main Protease of SARS‐CoV‐2 (ChemBioChem 23/2020)
Author(s) -
Plassche Merel A. T.,
BarniolXicota Marta,
Verhelst Steven H. L.
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000759
Subject(s) - front cover , cover (algebra) , covid-19 , protease , chemistry , combinatorial chemistry , virology , biochemistry , biology , enzyme , medicine , engineering , mechanical engineering , disease , pathology , outbreak , infectious disease (medical specialty)
A mock video game of pandemic outbreaks illustrates how scientists around the globe with various resources are tackling missions in the combat against Covid‐19. In their full paper, S. H. L. Verhelst et al. describe the development of an activity‐based probe to selectively detect the active Main protease of SARS‐CoV2. This probe is armed with a cysteine‐reactive acyloxymethyl ketone warhead and a substrate‐based peptide skeleton that allow it to detect the protease even in a complex human proteome.