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Cover Feature: Towards Zwitterionic Oligonucleotides with Improved Properties: the NAA/LNA‐Gapmer Approach (ChemBioChem 22/2020)
Author(s) -
Wojtyniak Melissa,
Schmidtgall Boris,
Kirsch Philine,
Ducho Christian
Publication year - 2020
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000733
Subject(s) - oligonucleotide , chemistry , cover (algebra) , rna , biophysics , crystallography , dna , biochemistry , biology , mechanical engineering , engineering , gene
The cover feature picture shows our work on a gapmer oligonucleotide with a zwitterionic backbone structure in the central gap and two anionic outer segments. One key question was if and how such a gapmer would bind to RNA, that is, if it displays sufficient binding affinity and base‐pairing fidelity. The other key question was if it would be stable towards nuclease‐mediated degradation. Our paper reports on the favourable properties of the zwitterionic gapmer oligonucleotide regarding these and further aspects. More information can be found in the full paper by C. Ducho et al.