Premium
Chemically Diverse Multifunctional Peptide Platforms with Antimicrobial and Cell Adhesive Properties
Author(s) -
MartinGómez Helena,
OliverCervelló Lluís,
BuxaderaPalomero Judit,
Ginebra MariaPau,
MasMoruno Carles
Publication year - 2021
Publication title -
chembiochem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.05
H-Index - 126
eISSN - 1439-7633
pISSN - 1439-4227
DOI - 10.1002/cbic.202000670
Subject(s) - peptide , antimicrobial , surface modification , biomaterial , cell adhesion , mesenchymal stem cell , antimicrobial peptides , chemistry , tissue engineering , adhesion , adhesive , nanotechnology , combinatorial chemistry , cell , materials science , biomedical engineering , biochemistry , microbiology and biotechnology , biology , medicine , layer (electronics) , organic chemistry
Bacterial infections and incomplete biomaterial integration are major problems that can lead to the failure of medical implants. However, simultaneously addressing these two issues remains a challenge. Here, we present a chemical peptide library based on a multifunctional platform containing the antimicrobial peptide LF1‐11 and the cell‐adhesive motif RGD. The scaffolds were customized with catechol groups to ensure straightforward functionalization of the implant surface, and linkers of different length to assess the effect of peptide accessibility on the biological response. The peptidic platforms significantly improved the adhesion of mesenchymal stem cells and showed antimicrobial effects against Staphylococcus aureus . Of note is that peptides bearing spacers that were too long displayed the lowest efficiency. Subsequently, we designed a platform replacing linear RGD by cyclic RGD; this further enhanced eukaryotic cell adhesion while retaining excellent antimicrobial properties, thus being a suitable candidate for tissue engineering applications.